Interphase encompasses 3 phases: G1, S and G2.During interphase, cells are duplicating their material and synthesising proteins to prepare to divide.The cell cycle is made up of two main stages: interphase and mitosis.When does the duplication of DNA happen in interphase?.In the Cancer Cell CAM compare the length of time these cells spend in interphase to that for mitosis to occur. Actual stages of mitosis can be viewed at Animal Cell Mitosis.Ĭancer cells reproduce relatively quickly in culture. As in both G1 and G2, there is a Checkpoint in the middle of mitosis (Metaphase Checkpoint) that ensures the cell is ready to complete cell division. Mitosis is much shorter than interphase, lasting perhaps only one to two hours. All of the cell's energy is focused on the complex and orderly division into two similar daughter cells. Mitosis or M Phase: Cell growth and protein production stop at this stage in the cell cycle. At the end of this gap is another control checkpoint (G2 Checkpoint) to determine if the cell can now proceed to enter M (mitosis) and divide. Gap 2 (G2): During the gap between DNA synthesis and mitosis, the cell will continue to grow and produce new proteins. DNA replication occurs during this S (synthesis) phase.
S Phase: To produce two similar daughter cells, the complete DNA instructions in the cell must be duplicated. (Click on the Checkpoints animation, above.) An important cell cycle control mechanism activated during this period (G1 Checkpoint) ensures that everything is ready for DNA synthesis. Gap 1 (G1): Cells increase in size in Gap 1, produce RNA and synthesize protein. An example of the latter is a cell that has reached an end stage of development and will no longer divide (e.g. This may be a temporary resting period or more permanent. Gap 0 (G0): There are times when a cell will leave the cycle and quit dividing.
By studying molecular events in cells, scientists have determined that interphase can be divided into 4 steps: Gap 0 (G0), Gap 1 (G1), S (synthesis) phase, Gap 2 (G2). During this period, the cell is constantly synthesizing RNA, producing protein and growing in size. Interphase generally lasts at least 12 to 24 hours in mammalian tissue. Those interphase activities are indispensible in making the next mitosis possible. Interphase: Interphase, which appears to the eye to be a resting stage between cell divisions, is actually a period of diverse activities.
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